Selective dorsal rhizotomy: meta‐analysis of three randomized controlled trials

This study is a comparative analysis and meta‐analysis of three randomized clinical trials. Children with spastic diplegia received either 'selective’dorsal rhizotomy (SDR) plus physiotherapy (SDR+PT) or PT without SDR (PT‐only). Common outcome measures were used for spasticity (Ashworth scale) and function (Gross Motor Function Measure [GMFM]). Baseline and 9‐ to 12‐month outcome data were pooled (n=90). At baseline, 82 children were under 8 years old and 65 had Gross Motor Function Classification System level II or III disability. Pooled Ashworth data analysis confirmed a reduction of spasticity with SDR+PT (mean change score difference ‐1.2; Wilcoxon p<0.001). Pooled GMFM data revealed greater functional improvement with SDR+PT (difference in change score +4.0, p=0.008). Multivariate analysis in the SDR+PT group revealed a direct relationship between percentage of dorsal root tissue transected and functional improvement. SDR+PT is efficacious in reducing spasticity in children with spastic diplegia and has a small positive effect on gross motor function.

Selective dorsal rhizotomy: meta‐analysis of three randomized controlled trials Journal Articles