Journal article
Development of kindling-prone and kindling-resistant rats: selective breeding and electrophysiological studies
Abstract
Because of the growing need for an animal model of complex partial seizures based on a genetic predisposition, we combined the kindling model of epilepsy with selective-breeding procedures to develop two new lines (or strains) of rats that are kindling-prone or kindling-resistant. The selection of these strains was based on their rates of amygdala kindling. From a parent population of Long Evans hooded and Wistar rats, the males and females …
Authors
Racine RJ; Steingart M; McIntyre DC
Journal
Epilepsy Research, Vol. 35, No. 3, pp. 183–195
Publisher
Elsevier
Publication Date
July 1999
DOI
10.1016/s0920-1211(99)00013-3
ISSN
0920-1211