This chapter contains sections titled: Introduction Oxidative stress and use of antioxidants in cardiovascular prevention Renin‐angiotensin axis and impact of angiotensin‐converting enzyme (ACE) inhibitors Homocysteine and vascular disease Inflammation and cardiovascular disease Infection and cardiovascular disease Introduction Oxidative stress and use of antioxidants in cardiovascular prevention Renin‐angiotensin axis and impact of angiotensin‐converting enzyme (ACE) inhibitors Homocysteine and vascular disease Inflammation and cardiovascular disease Infection and cardiovascular disease