In this VERTICO early science paper we explore in detail how environmental mechanisms, identified in H
i, affect the resolved properties of molecular gas reservoirs in cluster galaxies. The molecular gas is probed using ALMA ACA (+TP) observations of 12CO(2–1) in 51 spiral galaxies in the Virgo cluster (of which 49 are detected), all of which are included in the VIVA H isurvey. The sample spans a stellar mass range of ideficiency and morphology. There is a weak correlation between global H iand H2 deficiencies, and resolved properties of molecular gas correlate with H ideficiency: galaxies that have large H ideficiencies have relatively steep and truncated molecular gas radial profiles, which is due to the removal of low-surface-density molecular gas on the outskirts. Therefore, while the environmental mechanisms observed in H ialso affect molecular gas reservoirs, there is only a moderate reduction of the total amount of molecular gas.