Risk evaluation using gene expression screening to monitor for acute cellular rejection in heart transplant recipients Academic Article uri icon

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abstract

  • Background

    Gene expression profiling (GEP) was developed for non-invasive surveillance of acute cellular rejection. Despite its widespread use, there has been a paucity in outcome data for patients managed with GEP outside of clinical trials.

    Methods

    The Outcomes AlloMap Registry (OAR) is an observational, prospective, multicenter study including patients aged ≥ 15 years and ≥ 55 days post-cardiac transplant. Primary outcome was death and a composite outcome of hemodynamically significant rejection, graft dysfunction, retransplantation, or death. Secondary outcomes included readmission rates and development of coronary allograft vasculopathy and malignancies.

    Results

    The study included 1,504 patients, who were predominantly Caucasian (69%), male (74%), and aged 54.1 ± 12.9 years. The prevalence of moderate to severe acute cellular rejection (≥2R) was 2.0% from 2 to 6 months and 2.2% after 6 months. In the OAR there was no association between higher GEP scores and coronary allograft vasculopathy (p = 0.25), cancer (p = 0.16), or non-cytomegalovirus infection (p = 0.10). Survival at 1, 2, and 5 years post-transplant was 99%, 98%, and 94%, respectively. The composite outcome occurred in 103 patients during the follow-up period. GEP scores in dual-organ recipients (heart-kidney and heart-liver) were comparable to heart-alone recipients.

    Conclusions

    This registry comprises the largest contemporary cohort of patients undergoing GEP for surveillance. Among patients selected for GEP surveillance, survival is excellent, and rates of acute rejection, graft dysfunction, readmission, and death are low.

authors

  • Moayedi, Yasbanoo
  • Foroutan, Farid
  • Miller, Robert JH
  • Fan, ChunPo S
  • Posada, Juan G Duero
  • Alhussein, Mosaad
  • Tremblay-Gravel, Maxime
  • Oro, Gabriela
  • Luikart, Helen I
  • Yee, James
  • Shullo, Michael A
  • Khush, Kiran K
  • Ross, Heather J
  • Teuteberg, Jeffrey J

publication date

  • January 2019