The Metabolomic Pathways of the Senescence‐Associated Secretory Phenotype in C2C12 Myoblasts

Cellular senescence is considered a hallmark of aging that often occurs in tissues and cells in response to DNA damage. Most healthy cells become senescent after a fixed number of divisions or irreparable genomic damage, often because of external conditions such as circulating factors that are released by adjacent senescent cells. These secreted factors, known as the senescence‐associated secretory phenotype (SASP), are capable of in vivo …