Purpose: The traumatic injuries distress scale (TIDS) is a tool to assess acute emotional distress after post-musculoskeletal injuries. The purpose of this study was to evaluate the psychometric properties of the Persian version of the TIDS (TIDS-P). Methods: Participants (n = 100, mean age = 32.5, 82% male) with acute musculoskeletal injuries of any etiology completed the TIDS-P and the Persian version of the Brief Pain Inventory (BPI-P) on a single occasion, with 15 completing a re-test in seven days. Structural validity (confirmatory factor analysis), criterion validity (Spearman's rho), internal consistency (Cronbach's alpha), and test-retest reliability (intra-class correlation coefficient, ICC2, 1) were assessed. Results: TIDS-P demonstrated excellent criterion validity as the correlation values were similar to the English version (r = 0.73, 0.56 versus 0.73 and 0.47, respectively). Adequate statistical criteria were demonstrated for the three-factor structure of TIDS-P (X2 = 88.15, df = 51, P < 0.001, CFI = 0.95, TLI = 0.96, and RMSEA = 0.086). The internal consistency was acceptable with Cronbach's alpha of 0.61 for the hyperarousal/intrusion subscale, 0.83 for the negative affect subscale, and 0.78 for the uncontrolled pain subscale. The ICC2, 1 values demonstrated excellent test-retest reliability (0.92). Conclusion: Evaluation of the psychometric properties of the TIDS-P provide excellent reliability and appropriate structural validity for assessment of emotional distress post-musculoskeletal injuries in Persian populations.