Zinc Deficiency Exacerbates Loss in Blood‐Brain Barrier Integrity Induced by Hyperoxia Measured by Dynamic MRI

Abstract. Using dynamic Magnetic Resonance Imaging (dMRI), blood‐brain barrier (BBB) permeability ( k PSρ ) and tissue interstitial leakage space ( v e ) were evaluated in zinc‐deficient (ZnDF) male weanling Wistar rats following 3 days exposure to hyperoxia (85% O 2 ). Temporal monitoring of T1‐weighted MR image changes, following a bolus intravenous injection of gadolinium‐DTPA, allowed estimation of BBB integrity. Three‐day exposure of …