Journal article
Cryoprotective agents influence viral dosage and thermal stability of inhalable dry powder vaccines
Abstract
Increasing viral dosage within dry powder vaccines reduces the powder mass required to elicit an immune response through pulmonary delivery. This work analyzes how cryoprotective agents affect viral activity, particle properties and thermal stability of a spray dried, inhalable vaccine vector under high viral loading. Stock suspensions of a human serotype 5 adenovirus (AdHu5) vector in either neat phosphate buffered saline (PBS), 10% glycerol …
Authors
Manser M; Feng X; Xing Z; Cranston ED; Thompson MR
Journal
International Journal of Pharmaceutics, Vol. 617, ,
Publisher
Elsevier
Publication Date
4 2022
DOI
10.1016/j.ijpharm.2022.121602
ISSN
0378-5173