Journal article
Defective insulin maturation in patients with type 2 diabetes
Abstract
OBJECTIVE: Progressive beta-cell dysfunction is a hallmark of type 2 diabetes (T2D). Increasing evidence indicates that over-stimulating proinsulin synthesis causes proinsulin misfolding and impairs insulin maturation and storage in db/db mice. However, defective insulin maturation in patients with T2D remains unknown.
METHODS: We examined intra-islet and intra-cellular distributions of proinsulin and insulin and proinsulin to insulin ratio in …
Authors
Huang Y; Zhen J; Liu T; Wang J; Li N; Yang J; Liang R; Wang S; Liu M
Journal
European Journal of Endocrinology, Vol. 185, No. 4, pp. 565–576
Publisher
Oxford University Press (OUP)
DOI
10.1530/eje-21-0144
ISSN
0804-4643