Journal article
Differential Role of B Cells and IL-17 Versus IFN-&ggr; During Early and Late Rejection of Pig Islet Xenografts in Mice
Abstract
BACKGROUND: Xenogeneic islet transplantation is an emerging therapeutic option for diabetic patients. However, immunological tolerance to xenogeneic islets remains a challenge.
METHODS: The current study used a pig-to-mouse discordant xenogeneic islet transplant model to examine antidonor xenogeneic immune responses during early and late rejection and to determine experimental therapeutic interventions that promote durable pig islet xenograft …
Authors
Kang HK; Wang S; Dangi A; Zhang X; Singh A; Zhang L; Rosati JM; Suarez-Pinzon W; Deng X; Chen X
Journal
Transplantation, Vol. 101, No. 8, pp. 1801–1810
Publisher
Wolters Kluwer
Publication Date
August 2017
DOI
10.1097/tp.0000000000001489
ISSN
0041-1337