Red‐ and Far‐Red‐Emitting Zinc Probes with Minimal Phototoxicity for Multiplexed Recording of Orchestrated Insulin Secretion

Zinc biology, featuring intertwining signaling networks and critical importance to human health, witnesses exciting opportunities in the big data era of physiology. Here, we report a class of red- and far-red-emitting Zn²⁺ probes with K_d values ranging from 190 nM to 74 μM, which are particularly suitable for real-time monitoring the high concentration of Zn²⁺ co-released with insulin during vesicular secretory events. Compared to the …