Journal article
A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation
Abstract
The aim of this study was to test whether radiation-induced bystander effects are involved in the response of multicellular systems to targeted irradiation. A primary explant technique was used that reconstructed the in vivo microarchitecture of normal urothelium with proliferating and differentiated cells present. Sections of human and porcine ureter were cultured as explants and irradiated on day 7 when the urothelial outgrowth formed a halo …
Authors
Belyakov OV; Folkard M; Mothersill C; Prise KM; Michael BD
Journal
British Journal of Cancer, Vol. 88, No. 5, pp. 767–774
Publisher
Springer Nature
Publication Date
March 2003
DOI
10.1038/sj.bjc.6600804
ISSN
0007-0920