Journal article
Characterization of the Cereulide NRPS α-Hydroxy Acid Specifying Modules: Activation of α-Keto Acids and Chiral Reduction on the Assembly Line
Abstract
Several nonribosomal peptide natural products are composites of alpha-hydroxy acid and alpha-amino acid monomers. Cereulide, the emetic toxin from the human pathogen Bacillus cereus, and valinomycin, from Streptomyces spp., are closely related macrocyclic K+ ionophores. The macrocyclic core of each natural product contains alternating peptide (six) and ester (six) bonds, and their cyclododecadepsipeptide structures consist of a …
Authors
Magarvey NA; Ehling-Schulz M; Walsh CT
Journal
Journal of the American Chemical Society, Vol. 128, No. 33, pp. 10698–10699
Publisher
American Chemical Society (ACS)
Publication Date
August 1, 2006
DOI
10.1021/ja0640187
ISSN
0002-7863