Emerging insights in the management of hemoglobin E beta thalassemia Academic Article uri icon

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  • Globally, hemoglobin (Hb) E β thalassemia accounts for approximately half the severe forms of β thalassemia. Because of its wide clinical diversity and the ability of patients with this condition to adapt unusually well to low hemoglobin levels, the management of Hb E β thalassemia, particularly the decision to instigate regular blood transfusion, is particularly difficult. Here, we present a summary of our work in patients with this condition, which attempts to define clinical, adaptive, and genetic factors of possible value in determining the early management of this condition.


  • Olivieri, Nancy F
  • Thayalsuthan, Vivekanandan
  • O’Donnell, Angela
  • Premawardhena, Anuja
  • Rigobon, Christopher
  • Muraca, Giulia
  • Fisher, Christopher
  • Weatherall, David J

publication date

  • August 2010