T cell–mediated autoimmunity in immune thrombocytopenia Journal Articles

abstract

• AbstractImmune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count and an increased risk of bleeding. In addition to anti‐platelet autoantibodies, CD8+ T cells have been implicated as a mechanism of platelet destruction. The current evidence for the existence of platelet‐specific CD8+ T cells in ITP is inconclusive. The purpose of this review is to summarize the studies that investigated CD8+ T cells in ITP and to review the methods that have been used to detect autoreactive CD8+ T cells in other autoimmune diseases.

authors

• Vrbensky, John R
• Nazy, Ishac
• Clare, Rumi
• Larche, Mark
• Arnold, Donald

status

• published 

publication date

• January 2022

has subject area

• 1102 Cardiorespiratory Medicine and Haematology (FoR)
• Apoptosis (MeSH)
• Autoantibodies (MeSH)
• Autoantigens (MeSH)
• Autoimmunity (MeSH)
• Biomarkers (MeSH)
• Blood Platelets (MeSH)
• CD8-Positive T-Lymphocytes (MeSH)
• Cytotoxicity, Immunologic (MeSH)
• Disease Management (MeSH)
• Disease Susceptibility (MeSH)
• Gene Expression Regulation (MeSH)
• Genes, MHC Class I (MeSH)
• Humans (MeSH)
• Immunology (Science Metrix)
• Lymphocyte Activation (MeSH)
• Purpura, Thrombocytopenic, Idiopathic (MeSH)
• T-Lymphocytes (MeSH)

published in

• European Journal of Haematology  Journal

keywords

• Apoptosis
• Autoantibodies
• Autoantigens
• Autoimmunity
• Biomarkers
• Blood Platelets
• CD8+ T cells
• CD8-Positive T-Lymphocytes
• Cytotoxicity, Immunologic
• Disease Management
• Disease Susceptibility
• Gene Expression Regulation
• Genes, MHC Class I
• Humans
• Lymphocyte Activation
• Purpura, Thrombocytopenic, Idiopathic
• T-Lymphocytes
• autoantibodies
• autoimmunity
• immune thrombocytopenia
• platelets

Digital Object Identifier (DOI)

• 10.1111/ejh.13705

PubMed ID

• 34487584

start page

• 18

end page

• 27

volume

• 108

issue

• 1