T cell–mediated autoimmunity in immune thrombocytopenia

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count and an increased risk of bleeding. In addition to anti-platelet autoantibodies, CD8⁺ T cells have been implicated as a mechanism of platelet destruction. The current evidence for the existence of platelet-specific CD8⁺ T cells in ITP is inconclusive. The purpose of this review is to summarize the studies that investigated CD8⁺ T cells in ITP and to review the methods that have been used to detect autoreactive CD8⁺ T cells in other autoimmune diseases.