Predicting Motor Outcome of Subthalamic Nucleus Deep Brain Stimulation for Parkinson’s Disease Using Quantitative Susceptibility Mapping and Radiomics: A Pilot Study Academic Article uri icon

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abstract

  • BackgroundEmerging evidence indicates that iron distribution is heterogeneous within the substantia nigra (SN) and it may reflect patient-specific trait of Parkinson’s Disease (PD). We assume it could account for variability in motor outcome of subthalamic nucleus deep brain stimulation (STN-DBS) in PD.ObjectiveTo investigate whether SN susceptibility features derived from radiomics with machine learning (RA-ML) can predict motor outcome of STN-DBS in PD.MethodsThirty-three PD patients underwent bilateral STN-DBS were recruited. The bilateral SN were segmented based on preoperative quantitative susceptibility mapping to extract susceptibility features using RA-ML. MDS-UPDRS III scores were recorded 1–3 days before and 6 months after STN-DBS surgery. Finally, we constructed three predictive models using logistic regression analyses: (1) the RA-ML model based on radiomics features, (2) the RA-ML+LCT (levodopa challenge test) response model which combined radiomics features with preoperative LCT response, (3) the LCT response model alone.ResultsFor the predictive performances of global motor outcome, the RA-ML model had 82% accuracy (AUC = 0.85), while the RA-ML+LCT response model had 74% accuracy (AUC = 0.83), and the LCT response model alone had 58% accuracy (AUC = 0.55). For the predictive performance of rigidity outcome, the accuracy of the RA-ML model was 80% (AUC = 0.85), superior to those of the RA-ML+LCT response model (76% accuracy, AUC = 0.82), and the LCT response model alone (58% accuracy, AUC = 0.42).ConclusionOur findings demonstrated that SN susceptibility features from radiomics could predict global motor and rigidity outcomes of STN-DBS in PD. This RA-ML predictive model might provide a novel approach to counsel candidates for STN-DBS.

authors

  • Liu, Yu
  • Xiao, Bin
  • Zhang, Chencheng
  • Li, Junchen
  • Lai, Yijie
  • Shi, Feng
  • Shen, Dinggang
  • Wang, Linbin
  • Sun, Bomin
  • Li, Yan
  • Jin, Zhijia
  • Wei, Hongjiang
  • Haacke, Mark
  • Zhou, Haiyan
  • Wang, Qian
  • Li, Dianyou
  • He, Naying
  • Yan, Fuhua

publication date

  • January 2021