Predicting the particle size distribution in twin screw granulation through acoustic emissions

A non-destructive process analytical technology for monitoring the complex particle size distributions inherent to twin screw granulation (TSG) was presented, based on acoustic emissions (AE). AE spectra were collected during the wet granulation of lactose monohydrate at different liquid to solid ratios from 8 to 14% and correlated with the particle size distributions (PSD) to train a neural network model. Predicted PSD for particle sizes from …