Journal article
PathFams: statistical detection of pathogen-associated protein domains
Abstract
BackgroundA substantial fraction of genes identified within bacterial genomes encode proteins of unknown function. Identifying which of these proteins represent potential virulence factors, and mapping their key virulence determinants, is a challenging but important goal.ResultsTo facilitate virulence factor discovery, we performed a comprehensive analysis of 17,929 protein domain families within the Pfam database, and scored them based on …
Authors
Lobb B; Tremblay BJ-M; Moreno-Hagelsieb G; Doxey AC
Journal
BMC Genomics, Vol. 22, No. 1,
Publisher
Springer Nature
DOI
10.1186/s12864-021-07982-8
ISSN
1471-2164