Journal article
The design and interpretation of pilot trials in clinical research in critical care
Abstract
BACKGROUND: Pilot trials are important to ensure that large randomized trials are rigorous, feasible, and economically justifiable. The objective of this review is to highlight the importance of randomized pilot trials and to describe key features of their design and interpretation using examples from critical care.
METHODS: We searched MEDLINE (1997-2007) and contacted experts to identify pilot randomized trials to exemplify and summarize …
Authors
Arnold DM; Burns KEA; Adhikari NKJ; Kho ME; Meade MO; Cook DJ
Journal
Critical Care Medicine, Vol. 37, No. 1, pp. s69–s74
Publisher
Wolters Kluwer
Publication Date
1 2009
DOI
10.1097/ccm.0b013e3181920e33
ISSN
0090-3493