Pilot Randomized Trials in Pediatric Critical Care

OBJECTIVES: Pilot trials are smaller randomized controlled trials conducted to inform the design and assess the feasibility of a large-scale trials. The objectives of this systematic review were to describe pilot trials in pediatric critical care, their conclusions about the clinical implications of the results, and the need for future research and to determine the frequency of large follow-up trials. DATA SOURCES: The Evidence in Pediatric …