Journal article
Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias
Abstract
BACKGROUND: Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an instrumental variable could help test …
Authors
Clarke R; Bennett DA; Parish S; Verhoef P; Dötsch-Klerk M; Lathrop M; Xu P; Nordestgaard BG; Holm H; Hopewell JC
Journal
PLOS Medicine, Vol. 9, No. 2,
Publisher
Public Library of Science (PLoS)
Publication Date
2 2012
DOI
10.1371/journal.pmed.1001177
ISSN
1549-1277