Journal article
Meta-analysis of genetic association studies under heterogeneity
Abstract
In multi-cohort genetic association studies or meta-analysis, associations of genetic variants with complex traits across cohorts may be heterogeneous because of genuine genetic diversity or differential biases or errors. To detect the associations of genes with heterogeneous associations across cohorts, new global fixed-effect (FE) and random-effects (RE) meta-analytic methods have been recently proposed. These global methods had improved …
Authors
Neupane B; Loeb M; Anand SS; Beyene J
Journal
European Journal of Human Genetics, Vol. 20, No. 11, pp. 1174–1181
Publisher
Springer Nature
Publication Date
11 2012
DOI
10.1038/ejhg.2012.75
ISSN
1018-4813