Variation in FTO contributes to childhood obesity and severe adult obesity Academic Article uri icon

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abstract

  • We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.

authors

  • Dina, Christian
  • Meyre, David Jean-Claude
  • Gallina, Sophie
  • Durand, Emmanuelle
  • Körner, Antje
  • Jacobson, Peter
  • Carlsson, Lena MS
  • Kiess, Wieland
  • Vatin, Vincent
  • Lecoeur, Cecile
  • Delplanque, Jérome
  • Vaillant, Emmanuel
  • Pattou, François
  • Ruiz, Juan
  • Weill, Jacques
  • Levy-Marchal, Claire
  • Horber, Fritz
  • Potoczna, Natascha
  • Hercberg, Serge
  • Le Stunff, Catherine
  • Bougnères, Pierre
  • Kovacs, Peter
  • Marre, Michel
  • Balkau, Beverley
  • Cauchi, Stéphane
  • Chèvre, Jean-Claude
  • Froguel, Philippe

publication date

  • June 2007

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