Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity" Academic Article uri icon

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abstract

  • Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.

authors

  • Dina, Christian
  • Meyre, David Jean-Claude
  • Samson, Chantal
  • Tichet, Jean
  • Marre, Michel
  • Jouret, Beatrice
  • Charles, Marie Aline
  • Balkau, Beverley
  • Froguel, Philippe

publication date

  • January 12, 2007