Study of TNFα -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population Academic Article uri icon

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abstract

  • OBJECTIVES: We investigated two genetic markers in pro inflammatory molecules : TNFalpha -308G/A and IL6 -174G/C in order to assess their effect on type 2 diabetes (T2D) and obesity in the Tunisian population. DESIGN AND METHODS: The study sample includes 228 patients with T2D and 300 healthy controls. Genotyping of IL6 -174G/C (rs1800795) was performed using Automated Dye Terminator Sequencing and of TNFalpha -308G/A (rs1800629) using the LightTyper technology. RESULTS: SNPs IL6 -174G/C and TNFalpha -308G/A are associated neither with T2D (p=0.89, p=0.34 respectively) nor with risk for overweight (p=0.86, p=0.12 respectively) in Tunisian population. Bonferroni correction showed that the founded association of IL6 -174G/C SNP with T2D susceptibility restricted to overweight patients (p(nominal)=0.03, p(corrected)=0.0033) is likely to be a random result. CONCLUSION: SNPs IL6 -174G/C and TNFalpha -308G/A are not major contributors to T2D or obesity risk in our Tunisian population.

authors

  • Bouhaha, Rym
  • Baroudi, Thouraya
  • Ennafaa, Hajer
  • Vaillant, Emanuel
  • Abid, Hafawa
  • Sassi, Rim
  • Vatin, Vincent
  • Froguel, Philippe
  • Gaaied, Amel Benammar-el
  • Meyre, David Jean-Claude
  • Vaxillaire, Martine

publication date

  • April 2010

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