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Circulating hematopoietic stem cells serve as...

Journal article

Circulating hematopoietic stem cells serve as novel targets for in utero gene therapy

Abstract

ABSTRACT In utero gene therapy has been proposed as a method for permanent correction of somatic disorders that affect the hematopoietic system before disease initiation (1, 2). However, clinical trials using transplantation of allogenic fetal liver, bone marrow, or adult stem cells have been unsuccessful, largely due to the failure of sustained hematopoietic reconstitution in fetal recipients (3). Here, we reveal that …

Authors

Murdoch B; Gallacher L; Awaraji C; Hess DA; Keeney M; Jay K; Chadwick K; Foley SR; Howson-Jan K; Chin Yee I

Journal

The FASEB Journal, Vol. 15, No. 9, pp. 1628–1630

Publisher

Wiley

Publication Date

7 2001

DOI

10.1096/fj.00-0654fje

ISSN

0892-6638

Associated Experts

Mick Bhatia

Professor, Faculty of Health Sciences

Ronan Foley

Professor Emeritus, Faculty of Health Sciences

Labels

Fields of Research (FoR)

3101 Biochemistry and cell biology 3208 Medical physiology

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