Assessment of the Quality of Recommendations from 161 Clinical Practice Guidelines Using the Appraisal of Guidelines for Research and Evaluation – Recommendations Excellence (AGREE-REX) Instrument Shows There Is Room for Improvement

Background: A new tool, the AGREE-REX, was recently developed to support the development, reporting, and assessment of clinical practice guidelines’ (CPGs) recommendations, and to complement the AGREE II tool. We assessed the credibility and implementability of 161 CPGs recommendations using the AGREE-REX draft tool.

Methods: Cross sectional study. CPGs were assessed by two independent appraisers using the AGREE-REX draft tool. The CPGs were …