Validation and Evaluation of Model-Based Crosstalk Compensation Method in Simultaneous ${}^{99{\rm m}}$ Tc Stress and ${}^{201}$ Tl Rest Myocardial Perfusion SPECT

Simultaneous acquisition of ${}^{99{\rm m}}$ Tc stress and ${}^{201}$ Tl rest myocardial perfusion SPECT has several potential advantages, but the image quality is degraded by crosstalk between the Tc and Tl data. We have previously developed a crosstalk model that includes estimates of the downscatter and Pb X-ray for use in crosstalk compensation. In this work, we validated the model by comparing the crosstalk from ${}^{99{\rm m}}$ Tc to the …