Feasibility study of 3D time‐reversal reconstruction of proton‐induced acoustic signals for dose verification in the head and the liver: A simulation study

PURPOSE: In vivo range and dose verification based on proton-induced acoustics (protoacoustics) is potentially a useful tool for proton therapy. Built upon our previous study with two-dimensional reconstruction, the time reversal (TR) method was extended to three-dimensional (3D) and evaluated at two treatment sites (head and liver) through simulation, with the emphasis on a number of aspects such as increased spatial coverage, computational …