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TNF Receptor Involvement in TNF-Mediated...
Journal article

TNF Receptor Involvement in TNF-Mediated Activities against Syngeneic Malignant and Normal Mouse Thymocytes

Abstract

Receptor-dependent tumor necrosis factor (TNF)-mediated activities against mouse thymoma cells and normal thymocytes syngeneic for C57 mice were examined to determine the specific involvement of TNF receptors R1 and R2. Both receptors are expressed by EL4 thymoma cells and normal C57 thymocytes. TNF-mediated activities included (a) cytotoxicity, (b) induction of hyposensitivity to TNF-mediated lysis, (c) costimulatory stimulation of thymocyte …

Authors

Fishman M; Larche M

Journal

Cellular Immunology, Vol. 152, No. 2, pp. 510–521

Publisher

Elsevier

Publication Date

12 1993

DOI

10.1006/cimm.1993.1308

ISSN

0008-8749