Early Onset of SARS-COV-2 Antibodies after First Dose of BNT162b2: Correlation with Age, Gender and BMI Journal Articles uri icon

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abstract

  • Background: The first goal of the study was to analyse the antibody titre 21 days after the first dose of the BNT162b2 vaccine in a group of 252 healthcare workers (HCW). The second goal was to analyse how the antibody titre changes in correlation with age, gender and body mass index (BMI). Methods: Participants had a nasopharyngeal swab for SARS-CoV-2 and were assessed for the presence of SARS-CoV-2 antibodies at baseline and 21 days after the BNT162b2 priming dose. Results: First dose of BNT162b2 activated immune responses in 98% of the participants. Five HWC had no increase in antibody titre 21 days after the first dose. Antibody titre was greater in young (<38 years) vs. older participants (<38 vs. 47–56 p = 0.002; <38 vs. >56 p = 0.001). Higher antibody levels were detected in underweight vs. pre-obesity group (p = 0.026) and in normal-weight vs. pre-obesity group (p = 0.007). This association was confirmed after adjusting for age (p = 0.0001) and gender (p = 0.00001). Conclusions: Our study demonstrates that a single dose of BNT162b2 activates the immune response, and being young and normal-weight correlate positively with this response. Larger specifically designed clinical trials are needed to validate these results.

authors

  • Pellini, Raul
  • Venuti, Aldo
  • Pimpinelli, Fulvia
  • Abril, Elva
  • Blandino, Giovanni
  • Campo, Flaminia
  • Conti, Laura
  • De Virgilio, Armando
  • De Marco, Federico
  • Di Domenico, Enea Gino
  • Di Bella, Ornella
  • Di Martino, Simona
  • Ensoli, Fabrizio
  • Giannarelli, Diana
  • Mandoj, Chiara
  • Manciocco, Valentina
  • Marchesi, Paolo
  • Mazzola, Francesco
  • Moretto, Silvia
  • Petruzzi, Gerardo
  • Petrone, Fabrizio
  • Pichi, Barbara
  • Pontone, Martina
  • Zocchi, Jacopo
  • Vidiri, Antonello
  • Vujovic, Branka
  • Piaggio, Giulia
  • Morrone, Aldo
  • Ciliberto, Gennaro

publication date

  • June 22, 2021