Journal article
Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells
Abstract
Embryonic stem (ES) cells may be used as an alternative source of functionally intact cardiomyocytes for ischemic heart disease. Several natural and synthetic small molecules have been identified as useful tools for controlling and manipulating stem cell renewal and differentiation. Currently, there is an urgent requirement for novel small molecules that specifically induce differentiation of stem cells into cardiomyocytes. To identify …
Authors
Oh S-W; Lee JB; Kim B; Jeon S; Kim M-K; Nam K-H; Ha J-R; Bhatia M; Oh GT; Kim D-Y
Journal
Archives of Pharmacal Research, Vol. 35, No. 11, pp. 1979–1988
Publisher
Springer Nature
Publication Date
November 2012
DOI
10.1007/s12272-012-1115-6
ISSN
0253-6269
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCell DifferentiationEmbryoid BodiesEmbryonic Stem CellsGreen Fluorescent ProteinsHeterocyclic Compounds, 4 or More RingsHigh-Throughput Screening AssaysHumansHydrocarbons, FluorinatedInduced Pluripotent Stem CellsMiceMice, Inbred C57BLMyocytes, CardiacMyosin Heavy ChainsPeptidomimeticsPromoter Regions, GeneticSmall Molecule Libraries