A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge Journal Articles uri icon

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  • Significance Hemagglutinin (HA) is the major influenza virus surface protein and a prime antigen candidate for vaccine development using recombinant subunit approaches. Adjuvants often are used to enhance the immunogenicity of recombinant proteins. Here, we show that a next-generation vaccine adjuvant system that seamlessly sequesters and presents antigens on the surface of immunogenic liposomes improves the functional immunogenicity of HA in mice and ferrets. The potential for antigen dose sparing and multivalent presentation is demonstrated using this approach.


  • Sia, Zachary R
  • He, Xuedan
  • Zhang, Ali
  • Ang, Jann C
  • Shao, Shuai
  • Seffouh, Amal
  • Huang, Wei-Chiao
  • D’Agostino, Michael R
  • Teimouri Dereshgi, Amir
  • Suryaprakash, Sambhara
  • Ortega, Joaquin
  • Andersen, Hanne
  • Miller, Matthew S
  • Davidson, Bruce A
  • Lovell, Jonathan F

publication date

  • June 2021