Human bones are vulnerable to injury from a wide range of events, such as falls, automotive crashes, and sporting collisions, to name a few. In order to evaluate protective measures, the injury limits of whole bones need to be established through impact testing, which is typically done on cadavers. This allows investigation of the factors that influence injury, and using statistical methods, safety limits can be established, which are used by industry to assess risk during various events. Furthermore, the injury tolerance of whole bones must be identified and translated to measures obtained using surrogates, such as anthropomorphic test devices (ATDs, or “crash test dummies”), in order to be used outside of the research lab environment. Lastly, an understanding of the factors that influence fracture allows development of better protective measures, thus reducing the incidence and severity of these debilitating injuries. Therefore, this chapter explains high-speed impact testing of whole bone, as well as how to analyze, present, and interpret results.