ChemInform Abstract: Synthesis of Substituted Isoquinolines via Pd‐Catalyzed Cross‐Coupling Approaches. Journal Articles uri icon

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abstract

  • AbstractA palladium‐catalyzed α‐ketone arylation of bromide (I) followed by a reductive amination is used for the preparation of β‐arylethylamines (IV), which are converted into desired isoquinolines (VI) by a microwave‐assisted Pictet—Spengler reaction and a subsequent dehydrogenation of intermediate tetrahydroisoquinolines.

publication date

  • March 27, 2012