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Thrombolytic Agents: Thrombosis‐Responsive...
Journal article

Thrombolytic Agents: Thrombosis‐Responsive Thrombolytic Coating Based on Thrombin‐Degradable Tissue Plasminogen Activator (t‐PA) Nanocapsules (Adv. Funct. Mater. 45/2017)

Abstract

In article number 1703934, Dan Li, Hong Chen, and co‐workers report a novel thrombolytic coating whose activity is triggered by thrombosis. The coated surfaces remain inert in normal plasma environment while releasing tissue plasminogen activator (t‐PA) and promoting fibrinolysis in response to thrombin. Such coating could avoid unfavorable complications caused by continuous release of antithrombotic agents.

Authors

Li C; Du H; Yang A; Jiang S; Li Z; Li D; Brash JL; Chen H

Journal

Advanced Functional Materials, Vol. 27, No. 45,

Publisher

Wiley

Publication Date

12 2017

DOI

10.1002/adfm.201770271

ISSN

1616-301X