Investigation of Non-Linear Adaptive Responses and Split Dose Recovery Induced by Ionizing Radiation in Three Human Epithelial Derived Cell Lines

Two almost completely exclusive fields in radiobiology deal with splitting doses of radiation and comparing the effect to a similar total dose given in one exposure. In radiotherapy, dose "fractionation" is used to "spare" normal tissue and in the low dose field, the adaptive response is well documented as a phenomenon where a small "priming" dose administered before the larger "challenge" dose reduces the effect of the large dose. There have …