Quality of life and long-term outcomes after hospitalization for COVID-19: Protocol for a prospective cohort study (Coalition VII). Academic Article uri icon

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abstract

  • INTRODUCTION: The long-term effects caused by COVID-19 are unknown. The present study aims to assess factors associated with health-related quality of life and long-term outcomes among survivors of hospitalization for COVID-19 in Brazil. METHODS: This is a multicenter prospective cohort study nested in five randomized clinical trials designed to assess the effects of specific COVID-19 treatments in over 50 centers in Brazil. Adult survivors of hospitalization due to proven or suspected SARS-CoV-2 infection will be followed-up for a period of 1 year by means of structured telephone interviews. The primary outcome is the 1-year utility score of health-related quality of life assessed by the EuroQol-5D3L. Secondary outcomes include all-cause mortality, major cardiovascular events, rehospitalizations, return to work or study, physical functional status assessed by the Lawton-Brody Instrumental Activities of Daily Living, dyspnea assessed by the modified Medical Research Council dyspnea scale, need for long-term ventilatory support, symptoms of anxiety and depression assessed by the Hospital Anxiety and Depression Scale, symptoms of posttraumatic stress disorder assessed by the Impact of Event Scale-Revised, and self-rated health assessed by the EuroQol-5D3L Visual Analog Scale. Generalized estimated equations will be performed to test the association between five sets of variables (1- demographic characteristics, 2- premorbid state of health, 3- characteristics of acute illness, 4- specific COVID-19 treatments received, and 5- time-updated postdischarge variables) and outcomes. ETHICS AND DISSEMINATION: The study protocol was approved by the Research Ethics Committee of all participant institutions. The results will be disseminated through conferences and peer-reviewed journals.

authors

  • Rosa, Regis Goulart
  • Robinson, Caroline Cabral
  • Veiga, Viviane Cordeiro
  • Cavalcanti, Alexandre Biasi
  • Azevedo, Luciano César Pontes de
  • Machado, Flávia Ribeiro
  • Berwanger, Otavio
  • Avezum, Álvaro
  • Lopes, Renato Delascio
  • Lisboa, Thiago Costa
  • Teixeira, Cassiano
  • Zampieri, Fernando Godinho
  • Tomazini, Bruno Martins
  • Kawano-Dourado, Letícia
  • Schneider, Daniel
  • Souza, Denise de
  • Santos, Rosa da Rosa Minho Dos
  • Silva, Sabrina Souza da
  • Trott, Geraldine
  • Gimenes, Bruna Dos Passos
  • Souza, Ana Paula de
  • Barroso, Bruna Machado
  • Costa, Lauren Sezerá
  • Brognoli, Liége Gregoletto
  • Pelliccioli, Melissa Pezzetti
  • Studier, Nicole Dos Santos
  • Schardosim, Raíne Fogliati de Carli
  • Haubert, Tainá Aparecida
  • Pallaoro, Victoria Emanuele Lobo
  • Oliveira, Debora Mariani de
  • Velho, Pedro Isaacsson
  • Medeiros, Gregory Saraiva
  • Gazzana, Marcelo Basso
  • Zavascki, Alexandre Prehn
  • Pitrez, Paulo Márcio
  • Oliveira, Roselaine Pinheiro de
  • Polanczyk, Carisi Anne
  • Nasi, Luiz Antônio
  • Hammes, Luciano Serpa
  • Falavigna, Maicon

publication date

  • January 2021