Journal article
Pulmonary hypertension is attenuated and ventilation-perfusion matching is maintained during chronic hypoxia in deer mice native to high altitude
Abstract
Hypoxia at high altitude can constrain metabolism and performance and can elicit physiological adjustments that are deleterious to health and fitness. Hypoxic pulmonary hypertension is a particularly serious and maladaptive response to chronic hypoxia, which results from vasoconstriction and pathological remodeling of pulmonary arteries, and can lead to pulmonary edema and right ventricle hypertrophy. We investigated whether deer mice (Peromyscu…
Authors
West CM; Wearing OH; Rhem RG; Scott GR
Journal
AJP Regulatory Integrative and Comparative Physiology, Vol. 320, No. 6, pp. r800–r811
Publisher
American Physiological Society
Publication Date
June 1, 2021
DOI
10.1152/ajpregu.00282.2020
ISSN
0363-6119