Fasting and exercise differentially regulate BDNF mRNA expression in human skeletal muscle Journal Articles uri icon

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  • Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change in BDNF mRNA was observed following exercise, while fasting upregulated BDNF by ∼3.5-fold. These changes were dissociated from changes in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) following exercise (+2- to 15-fold) and fasting (∼–25%). These results challenge our understanding of the response of BDNF to energetic stress and highlight the importance of future work in this area.


  • Walsh, Jeremy
  • Edgett, Brittany A
  • Tschakovsky, Michael E
  • Gurd, Brendon J

publication date

  • January 2015

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