Journal article
Association of Urine Platinum With Acute Kidney Injury in Children Treated With Cisplatin for Cancer
Abstract
Cisplatin is a chemotherapeutic agent highly excreted in urine and known to cause acute kidney injury (AKI). As AKI diagnosis by serum creatinine (SCr) is usually delayed, endeavors for finding early AKI biomarkers continue. This study aims to determine if urine platinum (UP) concentration 24 hours after cisplatin infusion is associated with AKI, and to evaluate the association between urine platinum and tubular damage biomarkers: neutrophil …
Authors
Lebel A; Chui H; McMahon KR; Lim YJ; Macri J; Wang S; Devarajan P; Blydt‐Hansen TD; Zappitelli M; Urquhart BL
Journal
The Journal of Clinical Pharmacology, Vol. 61, No. 7, pp. 871–880
Publisher
Wiley
Publication Date
July 2021
DOI
10.1002/jcph.1839
ISSN
0091-2700