Damage to mammalian cell DNA by nitrofurans. Theses

abstract

• Maximum rates of nitrofuran reduction by intact mammalian cells and homogenates of mouse liver are obtained under anaerobic conditions, although significant reduction does occur with gas mixtures containing 5% oxygen and less. Single-strand breaks in DNA, measured as a decrease in the sedimentation constant on alkaline sucrose gradients, are produced in mammalian L929, KB, AND BHK-21 cells in vitro and Ehrlich ascites cells in vivo by several nitrofuran derivatives under hypoxic conditons.

authors

• Olive, PL
• Mccalla, Dennis Robert

publication date

• March 1975

has subject area

• 1112 Oncology and Carcinogenesis (FoR)
• Aerobiosis (MeSH)
• Anaerobiosis (MeSH)
• Animals (MeSH)
• Cells, Cultured (MeSH)
• Centrifugation, Density Gradient (MeSH)
• Cricetinae (MeSH)
• DNA (MeSH)
• Humans (MeSH)
• Liver (MeSH)
• Mice (MeSH)
• Nitrofurans (MeSH)
• Oncology & Carcinogenesis (Science Metrix)
• Oxidation-Reduction (MeSH)

published in

• Cancer Research  Journal

keywords

• Aerobiosis
• Anaerobiosis
• Animals
• Cells, Cultured
• Centrifugation, Density Gradient
• Cricetinae
• DNA
• Humans
• Liver
• Mice
• Nitrofurans
• Oxidation-Reduction