Journal article
YAP and endothelin-1 signaling: an emerging alliance in cancer
Abstract
The rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted therapies is fueled by the awareness that GPCR-initiated signaling acts as pivotal driver of the early stages of progression in a broad landscape of human malignancies. The endothelin-1 (ET-1) receptors (ET-1R), known as ETA receptor (ETAR) and ETB receptor (ETBR) that belong to the GPCR superfamily, affect both cancer initiation and progression in a variety …
Authors
Tocci P; Blandino G; Bagnato A
Journal
Journal of Experimental & Clinical Cancer Research, Vol. 40, No. 1,
Publisher
Springer Nature
DOI
10.1186/s13046-021-01827-8
ISSN
0392-9078