Journal article
Analysis of serum tranexamic acid in patients undergoing open heart surgery
Abstract
BACKGROUND: Tranexamic acid is a drug used during open cardiac surgery to prevent blood loss. The blood levels of 10-100 µg/mL are reported to be in the therapeutic range and higher levels are linked to increased incidence of adverse effects. The aim of this study was to optimize and validate an LC-MS/MS method for serum tranexamic acid and measure its levels in patients from the DEPOSITION Pilot trial in order to prove the concept that topical …
Authors
Ivica J; Gauthier J; Power P; Lamy A; Potter M
Journal
Clinical Biochemistry, Vol. 87, , pp. 74–78
Publisher
Elsevier
Publication Date
January 2021
DOI
10.1016/j.clinbiochem.2020.10.010
ISSN
0009-9120