ANCA-associated vasculitis patients treated in Polish intensive care units – retrospective characteristics based on the POLVAS registry Journal Articles uri icon

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  • INTRODUCTION: ANCA-associated vasculitides (AAV) is a group of rare disorders where inflammation and damage of the small blood vessels lead to dysfunction of the supplied organs. In severe flares of the disease patients may require intensive care unit (ICU) admission and treatment. The study aims to characterize Polish patients with AAV who were admitted to the ICU and compare them to the others. MATERIAL AND METHODS: An observational, retrospective study based on the POLVAS - registry of Polish adult patients with AAV was carried out. Patients admitted to the ICU (ICU group) were identified and compared with the patients who did not require ICU admission (non-ICU group). Characteristics and comparison between groups were made using standard statistic descriptive methods. RESULTS: 30 patients admitted to the ICU were identified among 573 cases included in the registry. All patients in the ICU group with available data were ANCA positive. The clinical manifestations related to the ICU admission were respiratory, renal and central nervous system involvement. The treatment regimen for remission induction was similar in both groups. Almost half of the patients in the ICU-group (48.3%) required dialysis, whereas in the non-ICU group it was 21.8% (P = 0.01). Infections were also more frequent in the ICU group (72.4% vs. 36.9% P < 0.001). The mortality rate among patients who needed ICU treatment was significantly higher when compared to the rest of the patients (53.6% vs. 7.8%; P < 0.001). CONCLUSIONS: In the Polish AAV cohort one in twenty patients required ICU admission. This group was characterized by multiple organ involvement and high mortality.


  • Włudarczyk, Anna
  • Biedroń, Grzegorz
  • Wójcik, Krzysztof
  • Zdrojewski, Zbigniew
  • Masiak, Anna
  • Czuszyńska, Zenobia
  • Majdan, Maria
  • Jeleniewicz, Radosław
  • Krajewska, Magdalena
  • Kusztal, Mariusz
  • Brzosko, Marek
  • Brzosko, Iwona
  • Dębska-Ślizień, Alicja
  • Storoniak, Hanna
  • Tłustochowicz, Witold
  • Kur-Zalewska, Joanna
  • Rydzewski, Andrzej
  • Madej, Marta
  • Hawrot-Kawecka, Anna
  • Stasiek, Małgorzata
  • Kucharz, Eugeniusz
  • Musial, Jacek
  • Szczeklik, Wojciech

publication date

  • 2020