GRADE approach to drawing conclusions from a network meta-analysis using a partially contextualised framework

This article describes GRADE (grading of recommendations assessment, development and evaluation) guidance on how to make conclusions from a network meta-analysis of interventions that includes individual randomised controlled trials for one outcome at a time. The guidance is based on a partially contextualised approach in which review authors must establish ranges of magnitudes of effect that represent a trivial to no effect, small but …