(p)ppGpp-Dependent Regulation of the Nucleotide Hydrolase PpnN Confers Complement Resistance in Salmonella enterica Serovar Typhimurium Academic Article uri icon

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  • The stringent response is an essential mechanism of metabolic reprogramming during environmental stress that is mediated by the nucleotide alarmones guanosine tetraphosphate and pentaphosphate [(p)ppGpp]. In addition to physiological adaptations, (p)ppGpp also regulates virulence programs in pathogenic bacteria, including Salmonella enterica serovar Typhimurium. S . Typhimurium is a common cause of acute gastroenteritis, but it may also spread to systemic tissues, resulting in severe clinical outcomes.


  • Chau, NY Elizabeth
  • Pérez-Morales, Deyanira
  • Elhenawy, Wael
  • Bustamante, Víctor H
  • Zhang, Yong E
  • Coombes, Brian

publication date

  • January 19, 2021