Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike Academic Article uri icon

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abstract

  • SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths. The Spike glycoproteins of SARS-CoV-2 mediate viral entry and are the main targets for neutralizing antibodies. Understanding the antibody response directed against SARS-CoV-2 is crucial for the development of vaccine, therapeutic, and public health interventions. Here, we perform a cross-sectional study on 106 SARS-CoV-2-infected individuals to evaluate humoral responses against SARS-CoV-2 Spike. Most infected individuals elicit anti-Spike antibodies within 2 weeks of the onset of symptoms. The levels of receptor binding domain (RBD)-specific immunoglobulin G (IgG) persist over time, and the levels of anti-RBD IgM decrease after symptom resolution. Although most individuals develop neutralizing antibodies within 2 weeks of infection, the level of neutralizing activity is significantly decreased over time. Our results highlight the importance of studying the persistence of neutralizing activity upon natural SARS-CoV-2 infection.

authors

  • Prévost, Jérémie
  • Gasser, Romain
  • Beaudoin-Bussières, Guillaume
  • Richard, Jonathan
  • Duerr, Ralf
  • Laumaea, Annemarie
  • Anand, Sai Priya
  • Goyette, Guillaume
  • Benlarbi, Mehdi
  • Ding, Shilei
  • Medjahed, Halima
  • Lewin, Antoine
  • Perreault, Josée
  • Tremblay, Tony
  • Gendron-Lepage, Gabrielle
  • Gauthier, Nicolas
  • Carrier, Marc
  • Marcoux, Diane
  • Piché, Alain
  • Lavoie, Myriam
  • Benoit, Alexandre
  • Loungnarath, Vilayvong
  • Brochu, Gino
  • Haddad, Elie
  • Stacey, Hannah D
  • Miller, Matthew S
  • Desforges, Marc
  • Talbot, Pierre J
  • Maule, Graham T Gould
  • Côté, Marceline
  • Therrien, Christian
  • Serhir, Bouchra
  • Bazin, Renée
  • Roger, Michel
  • Finzi, Andrés

publication date

  • October 2020