Developing trustworthy recommendations as part of an urgent response (1–2 weeks): a GRADE concept paper Academic Article uri icon

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abstract

  • OBJECTIVES: The aim of this study is to propose an approach for developing trustworthy recommendations as part of urgent responses (1-2 week) in the clinical, public health, and health systems fields. STUDY DESIGN AND SETTING: We conducted a review of the literature, outlined a draft approach, refined the concept through iterative discussions, a workshop by the Grading of Recommendations Assessment, Development and Evaluation Rapid Guidelines project group, and obtained feedback from the larger Grading of Recommendations Assessment, Development and Evaluation working group. RESULTS: A request for developing recommendations within 2 week is the usual trigger for an urgent response. Although the approach builds on the general principles of trustworthy guideline development, we highlight the following steps: (1) assess the level of urgency; (2) assess feasibility; (3) set up the organizational logistics; (4) specify the question(s); (5) collect the information needed; (6) assess the adequacy of identified information; (7) develop the recommendations using one of the 4 potential approaches: adopt existing recommendations, adapt existing recommendations, develop new recommendations using existing adequate systematic review, or develop new recommendations using expert panel input; and (8) consider an updating plan. CONCLUSION: An urgent response for developing recommendations requires building a cohesive, skilled, and highly motivated multidisciplinary team with the necessary clinical, scientific, and methodological expertise; adapting to shifting needs; complying with the principles of transparency; and properly managing conflicts of interest.

authors

  • Akl, Elie A
  • Morgan, Rebecca
  • Rooney, Andrew A
  • Beverly, Brandiese
  • Katikireddi, Srinivasa Vittal
  • Agarwal, Arnav
  • Alper, Brian S
  • Alva-Diaz, Carlos
  • Amato, Laura
  • Ansari, Mohammed T
  • Brozek, Jan
  • Chu, Derek
  • Dahm, Philipp
  • Darzi, Andrea J
  • Falavigna, Maicon
  • Gartlehner, Gerald
  • Pardo-Hernandez, Hector
  • King, Valerie
  • Klugarová, Jitka
  • Langendam, MW Miranda
  • Lockwood, Craig
  • Mammen, Manoj
  • Mathioudakis, Alexander G
  • McCaul, Michael
  • Meerpohl, Joerg J
  • Minozzi, Silvia
  • Mustafa, Reem Adel
  • Nonino, Francesco
  • Piggott, Thomas
  • Qaseem, Amir
  • Riva, John
  • Rodin, Rachel
  • Sekercioglu, Nigar
  • Skoetz, Nicole
  • Traversy, Gregory
  • Thayer, Kris
  • Schunemann, Holger

publication date

  • January 2021